top of page
Attacks cancer stem cells – the only agent with this capability
Unlike cytotoxic cancer treatments, Natural Killer (NK) cells are able to target and eliminate quiescent/non-proliferating cells such as cancer stem cells (CSCs), and these enigmatic cells are an important source of relapse and metastasis. CSCs are a small subpopulation of self-renewing malignant and oncogenic cells that drive tumor initiation and progression. There is increasing data demonstrating that NK cells can selectively identify and lyse CSCs.
Selected references:
Colorectal CSCs
Glioblastoma-derived CSCs
Melanoma cell lines with CSC characteristics
Breast CSCs
bottom of page